SAN FRANCISCO (California), ANI: Researchers have found that there is a slight change in the structure of the heart and dialystic function in the early days of adulthood and in middle age and this may be related to reduction in thinking and memory skills. . The research is published in the online journal Neurology of the American Academy of Neurology.
Diallastic function refers to the filling of blood in the chambers of the heart and the rest between bits. The author of the research, Laure Rouch, from the University of California, San Francisco, said that the risk of cardiovascular diseases has been associated with high blood pressure, high cholesterol and diabetes. But little is known about the cognitive risk associated with the structure and function of the heart.
He explained that we studied young people reaching middle age for 25 years and found that deficits in thinking and memory skills are separate or independent of the above factors. The significance of our findings is the association of markers in the heart with respect to the risk of cognitive impairment later in life. Such anomalies are usually common and often go unrecognized because they do not have any natural symptoms.
How did he study
The study included 2,653 people with an average age of 30. Echo-cardiograms, ultrasound images were taken of all participants at the start of the study. After 20 and 25 years this process was repeated. The researchers used these to measure the weight of the left ventricle (the left ventricle – the left lower part of the heart), the volume of blood it fills to pump, and how it pumps (in quantitative percentages) of blood to other parts of the body. Done to measure.
What did you find after 25 years
After 25 years, the researchers found that the average weight of the left ventricle increased by 0.27 grams per square meter per year (g/m2). It had an average weight gain of 81 g/m2 in the first year and 86 g/m2 in the last year. Left arterial blood volume also increased by 0.42 millilitres per square meter (ml/m2). In this, the average growth in the first year was 16 ml/m2 and in the last year 26 ml/m2. In the final year of the study, the participants were given six cognitive tests. It assessed thinking and memory skills including global cognition, processing speed, executive function, delayed verbal memory, and fluency. They were shown a list of words and asked to remember it 10 minutes later.
The researchers found that after adjusting for factors such as age, sex and education, the increase in left ventricle weight from early puberty to middle age was associated with lower levels in most cognitive tests in a person’s middle age.
In a general test of dementia, participants were given activities to draw lines and connect letters, repeating five words. Scores for this test ranged from zero to 30 and the highest general cognitive score was 26. Middle-aged participants who had an average weight gain in the left ventricle had an average score of 22.7 on these tests, while those who did not gain above average weight had a score of 24.
An increase in left atrial volume was also associated with a decrease in cognition in middle age. However, the above-average drop in the percentage of blood pumping from the left ventricle was not related to cognition. It was interesting to note that even after adjusting for the effects of cardiovascular disease factors such as high blood pressure, diabetes, smoking and obesity, the results were the same, Rouch said.
- Laure ROUCH, Tina Hoang, Feng Xia, Stephen Sidney, Joao A.C Lima, Kristine Yaffe. Twenty-Five–Year Change in Cardiac Structure and Function and Midlife Cognition: The CARDIA Study. Neurology, 2022